If you love pizza night but want something even easier and more comforting, this Pepperoni Biscuit Pizza Casserole is the perfect family-friendly dinner. It combines fluffy, golden biscuit pieces with savory pepperoni, rich pizza sauce, Italian seasoning, and plenty of gooey melted cheese.
Everything bakes together in one dish, creating crispy edges, soft buttery biscuit pieces, and a bubbling cheesy topping. It’s quick enough for a weeknight meal and hearty enough to feed the whole family.
Ingredients
- 2 cans refrigerated biscuit dough, cut into bite-sized pieces
- 1½ cups pizza or marinara sauce
- 1½ cups shredded mozzarella cheese
- 1 cup sliced pepperoni
- ½ cup shredded cheddar cheese, optional
- 2 tablespoons melted butter
- 1 teaspoon Italian seasoning
- ½ teaspoon garlic powder
- ¼ teaspoon onion powder
- ¼ teaspoon crushed red pepper flakes, optional
- 2 tablespoons grated Parmesan cheese
- Fresh parsley or basil, chopped, for garnish
Instructions
1. Prepare the Oven and Baking Dish
Preheat your oven to 375°F (190°C).
Lightly grease a 9×13-inch baking dish with cooking spray or a little butter.
2. Prepare the Biscuit Pieces
Cut each refrigerated biscuit into approximately 6–8 small pieces.
Place the biscuit pieces in a large bowl.
Pour the melted butter over them and sprinkle with Italian seasoning, garlic powder, and onion powder.
Toss gently until the biscuit pieces are evenly coated.
3. Build the Casserole
Spread about half of the pizza sauce over the bottom of the prepared baking dish.
Add half of the seasoned biscuit pieces.
Scatter half of the pepperoni over the biscuits, followed by half of the mozzarella and cheddar if using.
Add the remaining biscuit pieces and spoon the remaining pizza sauce over the top.
Finish with the remaining pepperoni and a generous layer of mozzarella.
Sprinkle Parmesan and optional red pepper flakes over everything.
4. Bake
Cover the dish loosely with aluminum foil and bake for 20 minutes.
Remove the foil and continue baking for another 15–20 minutes, until the biscuits are cooked through and the cheese is melted, bubbling, and lightly golden.
If you want a more deeply browned cheese topping, place the casserole under the broiler for 1–2 minutes at the end. Watch it carefully.
5. Rest and Serve
Remove the casserole from the oven and let it rest for about 5–10 minutes.
Garnish with fresh parsley or basil before serving.
Spoon the warm casserole onto plates and enjoy while the cheese is still gooey.
Tips for the Best Pizza Casserole
Cut the biscuits small. Smaller pieces cook more evenly and make every serving easier to scoop.
Don’t use too much sauce. Excess sauce can prevent the biscuit pieces from cooking properly.
Cover first, then uncover. The foil helps the biscuits cook without allowing the cheese to brown too quickly.
Check the center. The biscuit pieces in the middle should be fully cooked and no longer doughy.
Let it rest before serving. This gives the sauce and melted cheese a few minutes to settle.
Easy Variations
Supreme Pizza Casserole
Add diced bell peppers, mushrooms, black olives, and cooked Italian sausage.
Meat Lovers
Combine pepperoni with cooked ground beef, Italian sausage, ham, and bacon.
Vegetable Pizza
Leave out the pepperoni and add mushrooms, bell peppers, onions, spinach, olives, and tomatoes.
Spicy Pepperoni
Use hot pepperoni and add crushed red pepper flakes or sliced jalapeños.
Extra Cheesy
Add a layer of provolone or Monterey Jack along with the mozzarella.
What to Serve With It
This casserole is filling on its own, but it pairs nicely with:
- Caesar salad
- Garlic bread
- Roasted vegetables
- Simple green salad
- Steamed broccoli
- Garlic knots
A crisp green salad is particularly good alongside the rich, cheesy casserole.
Storage and Reheating
Store leftover casserole in an airtight container in the refrigerator for up to 3–4 days.
Reheat individual portions in the microwave, or warm larger portions covered with foil in a 350°F (175°C) oven until heated through.
For the best texture, avoid repeatedly reheating the entire casserole.
Recipe at a Glance
Prep Time: 15 minutes
Cook Time: 35–40 minutes
Resting Time: 5–10 minutes
Servings: 6–8
Oven Temperature: 375°F (190°C)
This Pepperoni Biscuit Pizza Casserole is everything you want from a comfort-food dinner: cheesy, saucy, savory, and wonderfully easy. With fluffy biscuit pieces standing in for traditional pizza crust, it delivers all the familiar flavors of pepperoni pizza in a warm, satisfying casserole that’s perfect for busy weeknights and casual family dinners.